Dopamine is a well known neurotransmitter present in the body. It has been established that dopamine levels act as an indicator for certain neurological conditions like Parkinson’s disease and schizophrenia. Thus it is important to detect dopamine at the site of production rather than in biological fluids. This presentation will describe the development and characterization of Carbon Fibre Microelectrodes (CFMEs) modified with a new type of biomass derived conductive nanostructures, and demonstrate the use of this material as an effective coating for CFMEs enabling the in vivo detection of dopamine. CFME are small enough to be used in vivo to detect biomarkers. The material and material characterization will be discussed comparatively for the developed CFMEs and electrodes obtained with commercial carbon nanotubes. These new implantable microelectrodes provide enhanced sensitivity and the ability to detect sub-nM concentrations of dopamine, with better performance as compared to other CFME designs. These characteristics make this sensor particularly attractive for in vivo applications. The electrode design and selectivity against common interfering agents and its potential application for the in vivo detection of dopamine in zebrafish (Danio rerio) embryos will be described.

Electrochemical microbiosensor for detection of dopamine using biomass derived nanostructures

ACS Fall 2021

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