Aminocarbonylation is an important transformation of aryl halides and pseudohalides used in a range of synthetic contexts. An alternative aminocarbonylation using aryl C–N electrophiles represents a highly desirable process which would offer important synthetic advantages over current methods. An aminocarbonylation of aryl quaternary ammonium salts to produce diverse amides using a simple cobalt catalyst under visible light irradiation will be presented. The reaction is applicable to electronically varied aromatic substrates and accommodates a range of amine nucleophiles. Applications to complex substrates and a two-step approach to aryl C–H functionalization via an amination-carbonylation approach will be discussed.

Photochemical aminocarbonylation of aryl quaternary ammonium salts via cobalt catalysis

ACS Fall 2021

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