Heparan sulfate (HS) play roles in many important biological events, including cancer metastasis, anti-coagulation, and Alzheimer’s disease development. HS structures in nature are heterogeneous with a wide range of sulfation patterns and backbone structures. The interactions of HS with their biological partners are known to be significantly impacted by the fine structures of HS. Thus, for a thorough understanding of the structure-activity relationships of HS, it is critical that a large number of HS structures bearing well defined sulfation patterns are available. To date, synthetic methodologies towards HS are mostly target oriented leading to a small set of oligosaccharides. To overcome this challenge, in this talk, we will present our strategies for the preparation of large libraires of heparan sulfate oligosaccharides and mimetics. The extensive HS oligosaccharides and mimetics assembled would greatly accelerate the research on the understanding of the fascinating biological functions of HS.

Expedient synthesis of heparan sulfate oligosaccharide libraries and mimetics

ACS Fall 2021

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