Base-catalyzed reactions typically accomplish redox neutral transformations, such as the addition of pronucleophiles to electrophiles. Our group is developing new mechanistic platforms for base-promoted reductive and oxidative coupling reactions to expand the capabilities of basic chemistry. This talk will highlight the development and synthetic potential of these processes in the context of two new reactions. This includes the reductive defluorinative coupling of trifluoromethylarenes with electrophiles and the oxidative coupling of heteroarenes with nucleophiles.

New base-promoted reductive and oxidative coupling reactions

ACS Fall 2021

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