The Cumulative Aggregate Risk Evaluation System – Next Generation (CARES NG) model is an updated version of the previous CARES model developed in 2001. CARES NG is a probabilistic model that provides an intuitive and efficient tool designed to estimate aggregate and cumulative exposure to pesticides from foods, drinking water and consumer products. The software has undergone extensive upgrades to a cloud-based application built upon public data, updated exposure algorithms, and improved user functionality. The dietary (food and water) module utilizes US consumption data (National Health and Nutrition Examination Survey 2005 to 2010) translated to raw agricultural commodities (RAC) based on EPA’s recipe file. The dietary user interface allows input of residue values, processing factors, and percent crop treated with built in rules to create the appropriate distribution of values according to EPA SOP. Multiple approaches to estimating dietary exposure are available: acute non-temporal, multi day temporal (repeating diet and match diet), chronic, cancer and within day (event or minute based).<br/>The residential module consolidates the EPA 2012 residential SOPs for both handler and post-application exposure calculations into a simple decision tree containing the default parameter inputs. The residential user interface allows input of product use scenarios for a given residential use pattern with product-specific parameters.<br/>Progress on the dietary module will be presented and include a comparison of the CARES NG with the dietary model DEEM.

Cumulative aggregate risk evaluation system - next generation (CARES NG) model: Progress and next steps

ACS Fall 2021

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