Our laboratory has been actively pursuing novel methods to re-engage components of the immune system to induce a targeted immunological response to the site of infection. More specifically, we have established the framework for the use of small molecules to trigger the recruitment of endogenous and exogenous antibodies to the surface of bacterial cells. In this presentation, our efforts towards building synthetic immunotherapeutics against bacterial pathogens will be described. Our ultimate goal is to establish the fundamental framework of a non-traditional antibiotic therapy based on the specific recruitment of antibodies and immune cells to the surface of pathogenic bacteria.

Synthetic immunomodulator against bacterial pathogens

ACS Fall 2021

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