Co(III)-catalyzed alkenylation of pyridones by using terminal alkyne as reaction partner with high regioselectivity has been demonstrated for the first time. The reaction conditions are mild and works well with a wide range of substrate combinations. It also shows good functional group tolerance. It proceeds through cyclometallation followed by alkyne insertion and protodemetallation steps. The formation of five and seven membered cobaltacycle intermediate was also detected through high resolution mass spectrometry.

Cobalt(III)-Catalyzed C-6 Alkenylation of 2-pyridones by using Terminal Alkyne with High Regioselectivity

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27th CRSI National Symposium in Chemistry

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