A highly diastereoselective Michael addition-Mannich domino reaction with isocyanoacetate and o-alkynylarylimines was reported. The substituted tetrahydropyrroloquinolines were obtained with excellent diastereoselectivity (>20:1) under mild condition. The protecting groups of o-alkynylarylimines direct the stereoselectivity in the formation of products. Herein, we demonstrated the tetrahydropyrroloquinolines obtained in a single operation bearing up to four contagious chiral centers. The reaction possesses diverse substrate scope under mild condition. The reaction mechanism was proposed by performing the control experiments.

Protecting-group-directed diastereoselective synthesis of tetrahydropyrroloquionolines from o-alkynylarylimies

In order to view the entire gallery of posters, videos, and other materials, please click "Submissions" below. 

To find the Q&A for each poster category, please click "Sessions" below. 

To ask a question, simply click on the session of interest. You will see a list of video presentations to the right. Below each video area, you'll see a section entitled 'Q&A for this presentation'. Here you can post questions to the presenters. They will be notified, and you'll also be notified when they reply to your question. You can expect that notification by email, and you'll find the author's response here.

27th CRSI National Symposium in Chemistry

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.