The synthesis of hexahydropyrimidine derivatives have continuously been an intense assignment for researchers. Hexahydropyrimidines subsidiary compounds are natural dynamic compounds, and they are found in numerous common products1. Numerous derivatives of hexahydropyrimidine show a critical part in organic activities like antibacterial2, antitumor, and anti-inflammatory activities3 etc. Here, we have created an awfully productive way of synthesis of hexahydropyrimidine subsidiary by utilizing aziridine and azomethine ylide through [3+3] cycloaddition. happening as concerted or stepwise process. Cycloaddition reactions are among the foremost valuable engineered developments in natural chemistry. Of these changes, the concerted [4+2]- cycloaddition, the Diels- Alder reaction, is by distant the finest known and most broadly connected. However, although symmetry disallowed as a concerted process and lacking certifiable examples until recently, stepwise [3+3]- cycloadditions offer advantages for the synthesis of a substantial variety of heterocyclic compounds, and they are receiving considerable attention.

Synthesis of Hexahydropyrimidine derivatives using [3+3] cycloaddition reaction and insitu Generation of Azomethine Ylide as Dipolar Adduct.

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27th CRSI National Symposium in Chemistry

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