Background  
The corona virus disease 2019 (COVID-19) pandemic has caused a sudden significant increase in hospitalizations for pneumonia with multiorgan disease. COVID-19 is caused by the novel severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). SARS CoV-2 infection may be asymptomatic or it may cause a wide spectrum of symptoms, such as mild symptoms of upper respiratory tract infection and life- threatening sepsis. Vaccination is one of the ways to reduce severe symptoms of COVID-19 and have proven to be safe, effective and life-saving. Studies show that COVID-19 vaccines are effective at keeping people from getting COVID-19 also help keep from getting seriously ill even if they do get COVID-19. Like all vaccines, they do not fully protect everyone who is vaccinated.

Aim  
This study aims to determine the clinical description of the severity and mortality rate of COVID-19 patient who is treated in an isolation room Muhammadiyah Palangkaraya hospital and has received one or two shots of the inactivated COVID-19 vaccine.

Method  
This was a retrospective observational study conducted at a COVID-19 referral hospital. We reviewed all the data taken from the electronic health records of the hospital from June 2021 to August 2021. In this research, there are 38 patients who already vaccinated one or two shots with inactivated COVID-19 vaccine. 

Results  
From this study we found 38 patients consist of 19 (50%) females, 19 (50%) males. The age range was 22 to 78 years old; the mean age was 46,57. There are 16 (42,10%) with comorbid disease and 22 (57,89%) with no comorbid. Patients with one shot vaccine 14 (36,80%) and two shots 24 (63,20%). The severity with mild symptom 15 (39,50%) and severe symptom 23 (60,50%). Mortality has been estimated at 2,60% (1 female patient).

Discussion  
From this study we found all the COVID-19 patients who were treated in the isolation room Muhammadiyah Palangkaraya hospital already vaccinated with inactivated COVID-19 vaccine. They who already received two doses 63,20% and 57,89% have comorbid diseases consist of heart failure 13,63%; diabetic 4,54%; hypertension 18,18%; hyperthyroid 4,54%; obesity 31,81%. The severity with severe symptoms still high 60,50% but the mortality was low 2,60%. The COVID-19 patients still have high severe symptoms regardless of one or two doses vaccinated with inactivated COVID-19 vaccine but the mortality was low.

References  
1. Anant Parasher. COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J 2021;97:312–320.   
2. Robert M. Kaplana, Arnold Milsteina. Influence of a COVID-19 vaccine’s effectiveness and safety profile on vaccination acceptance. PNAS 2021 Vol. 118 No. 10  
3. Nawal Al Kaabi, MBBS; Yuntao Zhang, PhD; et al. Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults A Randomized Clinical Trial. JAMA . 2021;326(1):35-45.   
4. W. Joost Wiersinga, MD, PhD; Andrew Rhodes, MD, PhD; et al. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review. JAMA . 2020;324(8):782-793.   
5. Simran Preet Kaur, Vandana Gupta. COVID-19 Vaccine: A comprehensive status report. Virus Research 288 (2020) 198114



Mortality and severity among Covid-19 patients who already vaccinated with inactivated Covid-19 vaccine