The 1955 demonstration by Lord Todd that dinucleotides could be constructed using P(V)-based chemistry was rapidly discarded with the advent of Carruthers pioneering phosphoramidate platform. This discovery revolutionized the field and enabled much of what we take for granted today in the oligonucleotide world. Our lab has been interested in reinvestigating whether the native P(V)-based chemistry that Nature uses in her approach has any place in mainstream oligonucleotide synthesis. This talk will focus on our latest strides in this area of inquiry.

Reinventing the synthesis of nature’s favorite polymers: Oligonucleotides

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.