Flexible bioelectronics, integrated into a variety of accessories, seamlessly fitting to the skin, or even implanted in the living body, have been extensively researched and have made great progress in biomedical fields such as electronic skin, intelligent monitoring and human-machine interface. In particular, a significant interest of flexible bioelectronics lies in monitoring physiological signals, revealing timely information on the state of our body and further providing actionable feedback for disease treatment to sustain a healthy lifestyle. However, the device power source still faces the limitation of large size, rigidity and short working life. If wearable electronic devices can be attached to a living body to collect energy generated by low-frequency motion and directly drive a flexible smart biomedical device, the nonnegligible problem of the size, rigidity and working life can be solved.<br/><br/>Here, we present a novel symbiotic non-pharmacological therapy system through low-invasive electrical intervention methods, including a wearable hair regeneration device, an implantable weight loss device and a biodegradable tissue repair device, emphasizing their role in biomedical applications in vivo and problems in practical applications. The work of weight loss provides an efficient and low-invasive strategy, and the weight of the device-implanted rat group was reduced by ~40% compared with the control group. A closed-loop feedback regulation system through food intake, gastric motion, electrical neuromodulation and brain control was established. Meanwhile, in the experiments of hair regeneration and tissue repair, the non-pharmacological electrical stimulation can regulate secretion of multiple growth factors, promote cell proliferation, and ultimately achieve the efficient repair effect. In general, due to the non-pharmacological and low-invasive nature, the widespread application of symbiotic bioelectronics will effectively treat more diseases or symptoms.

Flexible bioelectronics for precise health management

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.