Research efforts on the UK-2A natural product have led to the development of two new fungicidal active ingredients trademarked by Corteva Agriscience: InatreqTM active (fenpicoxamid) and AdaveltTM active (florylpicoxamid). During subsequent structure-activity relationship investigations, an unexpected byproduct was found. This observation led to the identification of a new picolinamide scaffold possessing unconventional stereochemical features and exciting fungicidal activity. Details on the synthesis and attributes of this novel picolinamide series will be reviewed.

Unique picolinamides for fungal disease control

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.