This talk will present the strategic bond disconnections of an aminoquinoline NLRP3 Agonist to enable a convergent synthesis. In addition to the overall synthetic route design, the process development of several key steps will be presented with a focus on process robustness, simplicity, and sustainability to provide high quality drug substance to enable clinical studies.

Design and development of a convergent synthesis of an aminoquinoline NLRP3 agonist

ACS Spring 2022

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