Since the discovery of N-heterocyclic carbenes (NHC’s) as a stable carbene, several various classes of NHC’s were synthesized, and their application as a ligand in metal complexes has received much attention to strong σ-donor with deficient π-acceptor nature. Our group had synthesized the first-ever achiral CCC-NHC pincer ligand and its zirconium amido pincer complex in 2005. We herein report the synthesis of the first-ever chiral CCC-NHC ligands and their zirconium and platinum pincer complexes by following <i>in-situ</i> metalation and transmetalation methodology. Synthesis of chiral CCC-NHC has been achieved by five-step synthesis, and the product is purified by using column chromatography and characterized by NMR, HR-MS, and polarimeter for measuring the optical rotation of the ligands. A high yield of chiral CCC-NHC pincer ligand and its transition metal complexes have been achieved.

Synthesis of first-ever chiral CCC-NHC pincer ligands and their transition metal complexes

ACS Spring 2022

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