Supramolecular drug self-delivery systems involving active drugs as building blocks linked by supramolecular interactions have been well defined as an advanced chemotherapy strategy. However, the lack of real-time feedback on drug release at tumor sites inevitably leads to unsatisfactory therapeutic effects, owing to the lack of information regarding the administration of these drugs. In this work, we designed platinum-containing drug-based supramolecular polymer (PtSPD) based on the host-guest interactions of two functionalized drug molecules cisplatin and gemcitabine. Then, PtSPD further self-assembled into platinum-based supramolecular micelles (PtSMs) in aqueous solution. The obtained PtSMs could be timely monitored by computed tomography imaging, immediately reflecting the evolution of drug release and real-time treatment at the tumor site. The appropriate administration about drug dosage and injection interval (1.2 mg mL<sup>−1</sup>, 100 μL, once every 3 days) could be precisely defined according to the therapeutic feedback. Therefore, the Pt-based self-tracked PtSPD may offer new potential opportunities for application in the field of efficient synergistic chemotherapy.

Platinum-containing drug-based supramolecular polymer realizing self-tracking in tumor

ACS Spring 2022

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