Polycyclic hydrocarbons are frequently viewed within medicinal chemistry as valuable bioisosteres of aryl or alkyl units that can increase the degree of lipophilicity of a potential drug molecule. One of the challenges associated with the synthesis of targets that contain a polycyclic hydrocarbon unit lies within the available tools for modification or installation of functionality into the relatively unreactive hydrocarbon framework. Our research group has recently developed a non-metal promoted method for incorporation of a sulfonamide unit into a polycyclic hydrocarbon framework. Our progress toward the construction of a library of N-alkyl sulfonamides derived from a polycyclic hydrocarbon core will be presented and discussed.

Development of new synthetic approaches for the incorporation of sulfonamide units into polycyclic hydrocarbon scaffolds

ACS Spring 2022

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