Acridines and Acridinium ions are important class of hetero-aromatic compounds with broad research and industrial usefulness in the field of medicinal chemistry, dye, chemosensor, photo catalysis, solar cell and photovoltaic applications.1 Till date all the synthetic methods reported for their synthesis deal with construction of a new 6-membered ring through formation of any one or two bonds on suitably substituted aromatic precursors.2 These aromatic precursors are not commercially available, often difficult to prepare and require multiple steps, often involve application of toxic heavy metals, ligands or high energy precursors/intermediates. We have developed a FeCl3-alcohol catalyzed one-pot general synthetic method for both diversely substituted acridines and acridinium ions directly from easily available 1,3-diketones, amines and aldehydes using molecular oxygen as terminal oxidant to produce water as the only by-product.3 Later we have used some of these acridinium ions for multiple efficient and useful organic transformations, such as, C-C bond formation through C-H activation of azaheterocycles, quinolones from quinoline N-oxides,4 fluorination of olefins to generate aliphatic/aromatic a-fluoroketones, aromatization of various azaheterocycles,5 photocatalytic debenzylations of ethers and esters etc. In this presentation I will discuss about some of these efficient greener methodologies recently developed in our laboratory.

Greener synthetic access to different azaheterocycles and their photocatalytic functionalization

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.