Multidrug resistant (MDR) bacterial infections have become a global threat. We recently disclosed that the known IKK-β inhibitor IMD-0354 and subsequent analogues abrogate colistin resistance in several Gram-negative strains. Herein, we report the activity of a second-generation library of IMD-0354 analogues incorporating a benzimidazole moiety as an amide isostere. We identified several analogues that show increased colistin potentiation activity against the Gram-negative bacteria: <i>Klebsiella pneumoniae </i>and <i>Acinetobacter baumannii</i>.

Benzimidazole isosteres of salicylanilides are highly active colistin adjuvants

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.