Cancer is an unrelenting disease that is caused by the rapid division of mutated cells. One path for the treatment of cancer is the targeted inhibition of TopoisomeraseIIα. Topoisomerase is a class of enzymes that participate in the overwinding and underwinding of DNA. TopoisomeraseIIα is active during cell replication and especially active in cancerous cells. Thiosemicarbazones (TSC) are organic compounds that can form metal complexes that have anti-proliferative effects and can act as anticancer agents along with also having antifungal and antibacterial properties as shown in the literature. The ability of these compounds to act as anti-cancer agents can be attributed to their inhibition of topoisomerase. This study will focus on the synthesis and characterization of alloxan ethylthiosemicarbazone (ALL-ETSC) and its copper complex as well as a look at the bioactivity of the compounds on topoisomeraseIIα through an enzyme assay using varying concentrations. This project incorporates the various courses that are taken through the career of an undergraduate chemistry major, making it particularly suitable to be a senior undergraduate research project.

Synthesis, characterization, and bioactivity of alloxan ethylthiosemicarbazone and its copper derivative as an undergraduate research project

ACS Spring 2022

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