As a class of therapeutics, sulfonamides have exhibited a wide variety of biological applications including antibacterial, anticancer, and anti-inflammatory activities. The incorporation of sulfonamide functionality into a molecular scaffold is a valuable goal within the realm of medicinal synthetic chemistry. In order to prepare a library of compounds that contain a sulfonamide unit attached to a polycyclic hydrocarbon (PH) core to test for biological activity, we have synthesized a number of PH-containing analogs by variation of the aryl component of the installed sulfonamide unit. The compounds were then subjected to a screening against mammalian cell lines to determine their cytotoxicity and the results of this study will be presented and discussed.

Investigation of the effect of aryl substituents on the biological activity of N-alkyl sulfonamides derived from polycyclic hydrocarbon scaffolds

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.