A circadian rhythm is a natural, internal process “clock” that regulates cellular responses to the environment, ranging from photosynthesis in plants to the sleep and wake cycles in mammals and disruption of this cycle has been linked to a variety of diseases. However, the molecular mechanism of regulation of this internal biological clock which involves complex interactions between transcription factors, period genes, cryptochromes, kinases, phosphatases and several other associated factors remains poorly understood. Therefore, using integrative modeling methods, we have been studying clock proteins involved in the maintenance of the circadian rhythm. In particular, we have studied mammalian cryptochrome proteins and demonstrated that difference in dynamics around their secondary pocket could be responsible for functional divergence in terms of transcriptional repression and period length observed <i>in vivo</i>.

Molecular mechanisms involved in the regulation of the Circadian Clock

ACS Spring 2022

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