Direct asymmetric reductive amination represents an efficient means of converting ketones to a-chiral primary amines but reported examples are very limited.  The development of two sets of Ru-catalyzed conditions for the direct conversion of an aryl methyl ketone to a pharmaceutically relevant chiral primary amine with high chiral purity will be described.

Development and scale-up of a direct asymmetric reductive amination with ammonia

ACS Spring 2022

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