Reactive oxygen species (ROS) are essential to cellular function but in diseased states elevated levels cause oxidative stress. Skin cancer the most prevalent type of diagnosed cancer in the world is caused by ultraviolet radiation (UVR). Studies show UVR exposure leads to overproduction of ROS through NADPH Oxidase (NOX) unique complex assembly. NOX inhibition is a key target for the prevention of cancers in skin. This research examines the efficacy of several novel NOX1 inhibitors to decrease damage after UVR. Through in vitro studies in primary skin cell cultures and human skin, the project assesses the toxicity of the inhibitors and their ability to protect against DNA damage caused by UVR. Several methods including MTT assays, UVR recovery assays, and NADPH oxidase activity assays are used to evaluate the inhibitors in primary cultures

Evaluation of NADPH oxidase inhibitors for reduction of ultraviolet oxidative damage in skin

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.