Metal-organic frameworks (MOFs), a group of cutting-edge designable porous scaffolding materials attracted attention in reticular chemistry, which has potentials to satisfy fundamental demands for delivery systems. Here, three types of curcumin-loaded UiO-66 (representative high biocompatibility and water-stable MOFs) delivery systems, curcumin-loaded UiO-66, curcumin-loaded UiO-66 high internal-phase Pickering emulsions (HIPPE) and curcumin loaded UiO-66 functional film were prepared, named as curcmin@UiO-66, curcumin@UiO-66 HIPPE, and curcumin@UiO-66/Chitosan, respectively. The loading capacity for these three delivery systems was reached 3.45% w/w, 7.33%, and 26.18%, respectively. All systems were characterized using X-ray diffraction (XRD), physisorption analyzer, scanning electron microscopy (SEM), and energy-dispersive X-ray spectrometer (EDS), for crystallography, morphology, physicochemical properties, with computer assistant optimization with DFT and GCMC simulation for maximum loading capacity. The result showed that these systems all exhibit extremely high surface area and porosity, as well as strong thermal stability as evidenced by TGA results, which demonstrated great potentials for application as a food delivery system. These novel MOF nanoparticle stabilized delivery systems are expected to be useful for other bioactive components and antimicrobial agents, which would find applications in functional food, food safety, and biomedical areas in the future.

Curcumin loaded metal-organic framework delivery systems

ACS Spring 2022

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