Alpha-amination of carbonyl compounds is an essential transformation that can enable the preparation of valuable amine products. Existing approaches to alpha-amination often rely on the use of pre-formed electrophilic nitrogen sources, and direct approaches to alpha-amination are limited. This presentation will discuss our latest results in developing an iron-catalyzed amination reaction that directly couples carbonyl compounds with amines, including preliminary mechanistic analysis.

Iron-catalyzed alpha-amination of ketones

ACS Spring 2022

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