The synthesis of novel compounds and identification of biological activity is at the foundation of medicinal chemistry and the pursuit of new pharmaceuticals. Previous research in our laboratory established an initial library of biologically active heteroaryl N-benzyl sulfonamides. It was observed that an indole core most frequently led to activity amongst the heteroarenes that were prepared. In an effort to synthesize compounds that improve upon our initial set of active compounds, an expanded library of indole sulfonamides was synthesized and cytotoxicity screening was performed to determine biological activity. The results of the library expansion and the <i>in vitro</i> screening assays will be presented and discussed.

Expansion of a synthesized library of heteroaryl N-benzyl sulfonamides and i<i>n vitro</i> detection of anticancer activity

ACS Spring 2022

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Expansion of a synthesized library of heteroaryl N-benzyl sulfonamides and in vitro detection of anticancer activity