Renowned for its biocompatibility, silk fibroin produced by the <i>Bombyx Mori</i> has proven to be successful in biomedical applications including drug delivery, implantable devices and tissue engineering. In this research, incorporation of non-native thiols to the tyrosine residues of silk fibroin was accomplished and characterized by 1D and 2D proton NMR, IR, Raman and UV. Adhesion properties of the thiol-modified silk to different surfaces and its ability to form inter- and intra-molecular crosslinks for gel formation will be presented.

Installation of cleavable disulfides into silk fibroin

ACS Spring 2022

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