Metal-organic frameworks (MOFs) can simply be defined as inorganic-organic hybrid compounds. They have shown extreme versatility in several areas of chemistry. One area of particular interest is in the area of drug delivery. This research presents the synthesis of several zinc metal-organic frameworks (Zn-MOFs) which are arbitrarily referred to as AB MOF-1, AB MOF-2, and AB MOF-3. These frameworks were synthesized by the reaction of zinc nitrate and 5-hydroxyisophthalic acid using multiple templates. The stability of the aforementioned structures along with the drug delivery potential was investigated using UV-Vis and X-Ray Powder Diffraction. The use of the novel <b>AB MOF 1</b> as a drug delivery vessel was investigated by monitoring the uptake and release of ibuprofen, erythromycin, acetaminophen and acetylsalicylic acid under physiological conditions.

Synthesis of zinc metal-organic materials for biomedical applications—drug delivery

ACS Spring 2022

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