Heparan sulfate is an essential class of glycosaminoglycans that plays important roles in a variety of biological processes, including protein-protein interaction, brain development, cancer metastasis, blood clotting, inflammation, and pathogen recognition of cells. Despite the recent advances in the chemical and chemoenzymatic synthesis of native heparan sulfates, it remains a sophisticated process to prepare heparan sulfates with defined sulfation patterns. In this presentation, I will present a novel approach to sequence-defined heparan sulfate mimetic polymers via “clickable dissacharides” monomers. This technique will enable facile assembly of heparan sulfate-mimetic main-chain polymers with defined sulfation patterns. The investigation of the specific interaction between these sulfated glycomimetic polymers and signaling molecules is anticipated to shed light on how sulfation patterns of heparan sulfates mediate cell adhesion and signaling, as well as provide affinity reagents for heparan sulfate-editing enzymes.

Facile synthesis of heparan sulfate-mimetic polymers with defined sulfation patterns

ACS Spring 2022

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