Oxovanadium(IV) complexes have numerous applications in diverse areas such as catalysts for organic transformations and as anti-fungal agents. Complexes that this research focused on have shown potential in acting as insulin mimetics. The goal of this research was to synthesis and fully characterize a new series of oxovanadium complexes and then investigate the insulin mimetic properties of the complexes with adipose cell culture work. Vanadyl complexes involving a series of Schiff-base ligands [C6H5N=CHC6H4OH (L1), 2,6-iPrC6H3N=CHC6H4OH (L2), C6H5N=CH-3,5-tBu2C6H2OH (L3), 2,6-iPrC6H3N=CH-3,5-tBu2C6H2OH (L4), and C6H11N=CHC6H4OH (L5)] were synthesized and structurally characterized. The ligand set was investigated due to the ease of sterically tuning the substituents on the ligand backbone to influence size and hydrophobicity of the resulting complexes. It is envisioned that such properties will play an important role in cellular uptake of these complexes. Reported here is the initial structural characterization of a series of complexes using FTIR and 1H-NMR spectroscopy, mass spectrometry, and X-ray crystallography.

Synthesis and characterization of oxovanadium compounds as potential insulin mimetic molecules

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.