Protein tyrosine phosphatase-1β (PTP1β) is responsible for the negative regulation of insulin signaling and a therapeutic target for diabetes, cancer, and inflammation. Tremendous growth has been made in finding PTP1β inhibitors that come from natural sources and exploring PTP1β regulatory mechanisms. Our results indicated that thymoquinone had a 69.1% inhibition and D-carvone had a 31.3% inhibition. The goal of our research is to determine the inhibitory mechanism of thymoquinone and D-carvone on protein tyrosine phosphatase-1β (PTP1β).

Mechanism of inhibition protein tyrosine phosphatase 1β (PTP1β) by terpenoids

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.