Polyisobutylene-based polyurethanes (PIB-PUs) containing approximately 70 wt.% PIB are biocompatible, biostable and calcification resistant thermoplastic elastomers (TPEs) of moderate cost for long term implantable medical devices. These TPEs have outstanding hydrolytic, oxidative, and enzymatic resistance, together with exceptional softness, barrier properties, low creep and low cell adhesion. The inert continuous PIB (-CH2-C(CH3)2-) soft segments shield the environmentally vulnerable urethane (-NHCOO-) hard segments and lead to exceptional biostability. Over the last decade several studies have been carried out to improve PIB-PU properties. However, we are unaware of disclosures of high molecular weight PIB-PUs with high mechanical properties. Herein we disclose the synthesis of PIB-PU containing 70 wt.% PIB with Mn &gt;100 kDa exhibiting 32 MPa ultimate strength and 630 % elongation. The synthesis was achieved by precisely controlled stoichiometry and using highly purified reagents. These PIB-PUs are designed for biomaterial applications where earlier PIB-PUs could not be used.

Synthesis of high MW and strength polyisobutylene-based polyurethane and its use for the development of a synthetic heart valve

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.