Stimuli-responsive polymeric nanoparticles with dynamic covalent bonds, exhibiting simultaneous multi-responsivity, open the door for the construction of a highly synchronized system in nanotechnology and biology-driven applications. Utilizing one-pot, photo-controlled atom transfer radical polymerization induced self-assembly (PhotoATR-PISA) mediated by UV light (λ = 365 nm) using parts per million (ppm) levels (ca. &lt;20 ppm) of a copper catalyst and without any work-up between stages, varied polymeric nanostructures morphologies, from nanospheres to worm-like micelles were obtained at ambient temperature. A series of well-defined, core cross-linked polymeric nanoparticles were prepared from the solvophilic poly(oligo(ethylene oxide) methyl ether methacrylate) (POEGMA) stabilizer via one-pot chain extension with glycidyl methacrylate (GMA) as core-forming, hydrophobic block, and N, N-cystamine bismethacrylamide (CBMA) and coumarin-methacrylate as cross-linking agents. The system demonstrated UV and redox stimuli-responsiveness via the coumarin [2+2] photocycloaddition/scission and DL-dithiothreitol (DTT) reduction of disulfide bonds, respectively. Fluorescence spectroscopy was utilized to verify the Nile red encapsulated NPs’ stimuli-responsiveness. It was displayed that each mentioned stimuli were able to trigger the Nile red release to some extent and show synergic effect for their simultaneous usage. In addition, the kinetics of release could be tailored by the pH of the surrounding medium. Thus, the system also showed pH-responsive controlled release behavior. These stimuli-responsive polymeric nanoparticles are being investigated for potential applications in biomedicines, targeted <i>in vivo</i> drug delivery, and water purification, to name a few.

Multi-stimuli-responsive Coumarin-based polymeric nanoparticle with high photo-switchable controlled release

ACS Spring 2022

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