The striking resemblance between biological one-dimensional structures and supramolecular polymers assembled in water inspired Sam Stupp and many other chemists to study these artificial mimics for possible biomedical applications. In our research we use water-soluble 1,3,5-benzene-tricarboxamides (BTAs) that from one-dimensional fibers in aqueous solution. By modifying the periphery of these BTAs, we can create biological relevant copolymers that can use their dynamic nature to adaptive their structure to rearrange the ligands accordingly to the receptors at the cell membrane. In the lecture, we will show that fundamental insights into the dynamic nature of these copolymers are essential to create function.

Supramolecular polymers as biomaterials; new avenues for the dynamic interaction with biological receptors

ACS Spring 2022

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