Organometallic reagents have emerged as tools for the efficient and selective conjugation of biomolecules within complex biological media. The precision and ease with which these reagents can perform numerous synthetic transformations has sparked investigations into the construction of atomically precise biomolecule-containing nanostructures. Here, we present rapid C-S bond formation via Me-DalPhos type (P,N) ligand supported Au(III) aryl complexes. Utilizing this strategy, we then detail the construction of atomically precise hybrid nanostructures. These nanostructures range from hybrid nanoparticles to bicyclic and asymmetric peptide conjugates. The synthesis and characterization of these nanostructures will be described.

Hybrid nanostructure construction via C-S arylation with organometallic Au(III) reagents

ACS Spring 2022

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