The thermodynamic properties of plasma membrane lipids play a vital role in many functions at the mammalian cell surface.  Some functions are thought to occur, at least in part, because plasma membrane lipids have a tendency to separate into two distinct liquid phases. This presentation will describe our recent efforts to probe the impact of membrane heterogeniety on protein functions using super-resolution fluorecence localization microscoply coupled with conventional assays of protein function.

Membrane phase transition and its impact on plasma membrane structure and function

ACS Spring 2022

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