The multicomponent synthesis of novel triazolodiazepines and related structures has been achieved using an Ugi 4-component reaction and [3+2] azide-alkyne cycloaddition cascade. The incorporation of environmentally friendly solvents and efforts at catalysis and microwave heating will also be described. The product structures are inspired by the triazolobenzodiazepine class of pharmaceuticals.

Ugi-4CR/[3+2] cascades to triazolodiazepines

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.