3-Aminoimidazo[1,2-a]pyridines and related structures have demonstrated a range of biological activities, including antimicrobial effects. We synthesized a series of 3-aminoimidazo[1,2-a]-heterocycles, some of which were novel, using a green, microwave-assisted Groebke-Blackburn-Bienaymé multicomponent reaction. Compounds with 4-chlorophenyl and tert-butyl substituents and varied core heterocyclic structures were found to exhibit antimicrobial activity against gram-positive bacteria.

Green Groebke-Blackburn-Bienaymé synthesis of 3-aminoimidazo[1,2-a]-heterocycles

ACS Spring 2022

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