<b>          </b>Non-invasive and convenient microneedles have been widely developed and applied for efficient transdermal drug delivery. However, it is still imperative to establish a simple and universal strategy to ensure a stable loading and delivery of nucleic acid-based drugs. Here, we developed a versatile RNA microneedle platform enabling the delivery of a large amount of RNA as well as other drugs. The RNA microneedle system is simply fabricated by direct coating MN with macroscopic RNA membrane which is comprised of self-assembled RNA, allowing full coverage of 3D-printed MN scaffold. Based on its high surface area, the RNA membrane-based coating approach enabled the fabrication of purpose-oriented microneedles with various shapes and materials of the microneedle scaffold, and types of drugs such as RNA, DNA, protein, and chemical. Notably, RNA microneedle enabled a rapid and simple transfer of a large amount of RNA to the porcine skin in several minutes via a single subcutaneous injection. The RNA microneedle platform would provide a universal manufacturing route towards the preparation of tailor-made microneedles for effective drug delivery.

Versatile RNA membrane-coated microneedles for subcutaneous drug delivery

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.