Reversible hierarchical self-assembly of molecules has been harnessed by living systems to control the formation of structures such as protein assemblies, cellular membranes, and cytoskeletal filaments, along with many others. By controlling multiple orthogonal interactions between molecules, we design supramolecular systems that mimic these reversible hierarchical processes. I will present on a supramolecular system in which exchange dynamics and host-guest interactions between β-cyclodextrin- and adamantane-functionalized peptide amphiphiles led to reversible superstructure formation. The host-guest interaction between the β-cyclodextrin and adamantane resulted in the generation of bundled nanoribbons to create a mechanically robust hydrogel with a highly porous architecture suitable for 3D printing. Functionalization of the porous superstructured material with a biological signal results in a matrix with enhanced neuronal infiltration and significant <i>in vitro</i> bioactivity. These reversible, hierarchical, and bioactive superstructures overcome the challenges of printing sensitive cell types while allowing the fabrication of complex brain tissue-like architectures. The combined benefits of bioactive chemical signaling and hierarchical superstructure formation, coupled with the ability to print self-supporting cell-laden hydrogels, make this an exciting biomaterial for tissue regeneration applications.

Controlling hierarchical superstructures in supramolecular polymers for tissue regeneration applications

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.