NanoCommons H2020 infrastructure project (www.nanocommons.eu) delivers a sustainable and openly accessible chem/nanoinformatics framework (knowledgebase and integrated computational tools, supported by expert advice, data interpretation and training), for the risk assessment of nanomaterials, their products and their formulations. The Enalos Cloud Platform, developed by NanoCommons partner NovaMechanics, offers users a suite of services covering data processing and analysis, including deep learning techniques for the extraction of valuable descriptors from nanomaterials and the identification of hazardous effects invisible to the naked eye in organisms (e.g., <i>Daphnia magna</i>) from microscopy images. NanoCommons offers a wide suite of predictive modelling tools, based on machine learning algorithms, for nanomaterials toxicity, biological activity and properties evaluation, based on open source and in house developed algorithms. These tools can be combined with partner and external tools for safe by design and risk assessment to support the design and development of novel, safer and fully functional nanomaterials.The tools have been complemented with user-friendly interfaces and are available as web services through the Enalos Cloud Platform, integrated within the NanoCommons e-infrastructure project. In this way, the tools are available to the nano-community and its broadest set of stakeholders (enterprise, regulators, insurance and society broadly), either for independent use or with expert support as needed. Here, we present selected examples: extraction of nanomaterials image descriptors from TEM images to enrich experimental descriptors and how these can be used to estimate the ζ-potential of other nanomaterials, prediction of protein binding and cytotoxicity for functionalized MWCNTs (with small molecules), predictive modelling for the analysis of the expression of genes profiling for carbon nanomaterials exposed cells, development of the extension of the InChI to represent nanomaterials.

European nanotechnology community informatics platform: Bridging data and disciplinary gaps for industry and regulators through data exploitation via the Enalos chem/nanoinformatics cloud platform

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.