The molecular recognition of polypeptides by synthetic compounds drives many areas of contemporary science and technology. We are focused on developing principles by which polypeptides can be targeted predictively on the basis of the sequence of amino acids. Studies using cucurbit[n]uril synthetic receptors have enabled the binding of N-terminal and non-terminal sites on polypeptides in neutral aqueous solution and with equilibrium dissociation constant values in the nanomolar to micromolar range. This presentation will cover the lessons learned from these studies with a view toward applications they enable.

Sequence predictive molecular recognition of polypeptides with synthetic receptors

ACS Spring 2022

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