C—H functionalization is an important strategy in organic synthesis. In-situ kinetic investigation in this work provided a comprehensive understanding of the reaction progress. The study on the model C—H insertion of cyclohexane experimentally revealed the rate-determine step is carbene insertion instead of carbene formation. The kinetic insights have driven rational optimization of the stoichiometry, carbene precursor structure, and additive of the reaction. As a result, about 580,000 Rh(II) catalyst turnover numbers have been achieved in the C—H insertion reaction. Broad C—H functionalization scopes with only 0.001 mol% Rh (II) catalyst loading have been explored and showed consistently great yield and excellent selectivity

In-situ kinetics studies of Rh(II)-catalyzed C—H functionalization to achieve high catalyst turnover numbers

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.