We have been interested in the utilization of the photophysical and photochemical properties of luminescent rhenium(I), ruthenium(II), and iridium(III) polypyridine complexes in the development of new biological reagents. The highly environment-sensitive and long-lived luminescence, and singlet oxygen photosensitization properties confer favorable diagnostic and therapeutic capabilities on these metal complexes. In this presentation, we will introduce our designs of luminescent transition metal polypyridine complexes containing different substituents such as poly(ethylene glycol), cyclooctyne, tetrazine, nitrone, sydnone, perfluorobiphenyl, and polysilsesquioxane. We will focus on the photophysical properties, bioorthogonal labeling, cellular uptake, organelle-targeting, and photocytotoxic activity of these complexes.

Photofunctional transition metal complexes for bioorthogonal labeling, bioconjugation, imaging, and photocytotoxic applications

ACS Spring 2022

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