Organic synthesis of new pharmaceuticals often focuses on modifying already existing compounds to create new or stronger activity that may improve a drug’s usefulness. Monoamine oxidase inhibitors (MAOi) can block the breakdown of neurotransmitters like dopamine, serotonin, and norepinephrine. They are most often used as antidepressants but can also be used to treat certain types of cancer. The focus of this work is to synthesize specific compounds with a cyclopropyl ring using the Simmons-Smith reaction. Because of their similar molecular structure to several MAOi, they may have potential medicinal properties. The cyclopropyl ring is a unique group because of its cis- and trans-isomers which may prove useful because it causes specific rigid orientations of the groups within the molecule which could increase the binding affinity to select enzymes. Future research could evaluate its medicinal properties.

Synthesis of novel cyclopropylamines as potentially medicinally active compounds

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.