We have been focused on developing the 72/77As diagnostic/therapeutic matched pair of radioisotopes for potential radiopharmaceutical applications. Arsenic-72 (72As) is an accelerator produced, 26-h half-life positron emitter, while 77As is a reactor produced, 38.8-h half-life beta emitter. Arsenic is thiophilic and chelate development has involved multidentate thiols (dithiols and trithiols). The production and separation chemistry, chelate and metal chemistry, radiotracer chemistry, specific activity and biological factors that have been addressed or need to be considered will be discussed with the ultimate goal of specific tumor targeting in mind.

Radioarsenic chemistry: Toward a diagnostic/therapeutic matched pair

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.