Cancer stem cell (CSC) model hypothesizes that most cancers are maintained by CSCs. CSCs exist as a small population in tumor. CSCs are resistant to the contemporary anti-cancer therapies, and hence become a root of tumor recurrence. Therefore, novel therapeutics targeting CSCs hold a great promise in eradicating breast cancer completely and therefore blocking tumor recurrence. We have developed a gold nanorod conjugate of synthetic binder of cancer stem cell, AuNR-CL-1-19-1. AuNR-CL-1-19-1 has exhibited excellent chemical and physical stability. We have found that AuNR-CL-1-19-1 binds selectively to CSC population over non-CSC population and laser irradiation induces selective inactivation of CSC population. Our effort in evaluating if tumor recurrence is blocked after gold nanorod-mediated hyperthermia will also be discussed.

Gold nanorod-mediated hyperthermia of cancer stem cells

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.