Cyclic dinucleotides are secondary messengers that play an important role in the innate immune response of eukaryotic cells. Chemical synthesis of cyclic dinucleotides is proven to be challenging due to the need for finely controlled selectivity as well as the lengthy manipulation of protecting groups. Biocatalysis has provided an alternative way to access these molecules in a highly selective manner. A library of enzymes that are capable of cyclic dinucleotide synthesis were identified through bioinformatic analysis. Cyclic dinucleotides with different substitution patterns were also synthesized using the chemoenzymatic method.

Biocatalytic cyclic dinucleotides synthesis

ACS Spring 2022

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