Photodynamic therapy (PDT) is an emerging clinical modality technique for cancer treatment that generates the reactive oxygen species such as singlet oxygen for cytotoxic effects. For example, TLD1433 is a ruthenium based polypyridyl pi-expansive oligothiophene metal complex developed by our lab that is in Phase II clinical trials for bladder cancer PDT. Here, we describe analogous Os(II) polypyridyl families derived from 4,4′-dimethoxy-2,2′-bipyridine as coligands associated with imidazo[4,5-f] [1,10] phenanthroline attached with pi-expansive oligothiophene [n =1-4] (IP-nT). The complexes were characterized by spectroscopically and their photophysical properties measured. Their photobiological activities were tested in vitro against SKMEL-28 cancer cells. These activities were compared against those for analogous Os(II) polypyridyl complexes to establish structure-activity relationships.

Role of methoxy substituents osmium polypyridyl pi-expansive metal complexes in photodynamic therapy

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.